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Ashwagandha is a natural herbal extract from a herb that is traditionally used to reduce stress and enhance wellbeing.* Ashwagandha is prolifically grown in dry regions of South Asia, Central Asia, and Africa, and is regularly used in Ayurveda, an ancient Hindu system of medicine. Ashwagandha has been traditionally used to promote “youthful vigour” by enhancing muscle strength, endurance, and overall health. Over 50 chemical constituents have been identified in the various parts of the ashwagandha plant with the major chemical constituents including steroidal alkaloids and lactones, collectively known as withanolides.*
How Ashwagandha Works
How do Withanolides Work?
Natural Hormonal Support Withanolides are a group of at least 300 naturally occurring steroids built on an ergostane skeleton.
Withanolides are Secondary metabolites, also called specialised metabolites, toxins, secondary products, or natural products, are organic compounds produced by bacteria, fungi, or plants which are not directly involved in the normal growth, development, or reproduction of the organism. Instead, they generally mediate ecological interactions, which may produce a selective advantage for the organism by increasing its survivability or fecundity. Specific secondary metabolites are often restricted to a narrow set of species within a phylogenetic group. Secondary metabolites often play an important role in plant defense against herbivory and other interspecies defenses. Humans use secondary metabolites as medicines, flavourings, pigments, and recreational drugs.
 - source wikipedia - https://en.wikipedia.org/wiki/Secondary_metabolite
Ashwagandha is best known for its stress-lowering effects.
The medicinal herb appears to help lower levels of cortisol, a hormone produced by your adrenal glands in response to stress. More specifically, daily doses of 125 mg to 5 grams for 1–3 months have shown to lower cortisol levels by 11–32% (2, 3Trusted Source, 4Trusted Source).
Moreover, 500–600 mg of ashwagandha per day for 6–12 weeks may reduce anxiety and lower the likelihood of insomnia in people with stress and anxiety disorders (3Trusted Source, 5Trusted Source, 6Trusted Source).kaloids and lactones, collectively known as withanolides.*
Brain Function Support
2000 Aug;5(4):334-46. L C Mishra 1, B B Singh, S Dagenais PMID: 10956379 Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review
Results: Studies indicate ashwagandha possesses anti-inflammatory, antitumor, antistress, antioxidant, immunomodulatory, hemopoietic, and rejuvenating properties. It also appears to exert a positive influence on the endocrine, cardiopulmonary, and central nervous systems. The mechanisms of action for these properties are not fully understood. Toxicity studies reveal that ashwagandha appears to be a safe compound. Link - https://pubmed.ncbi.nlm.nih.gov/10956379/
J Diet Suppl 2017 Nov 2;14(6):599-612. doi: 10.1080/19390211.2017.1284970. Epub 2017 Feb 21. PMID: 28471731 Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions
Results: After eight weeks of study, the ashwagandha treatment group demonstrated significant improvements compared with the placebo group in both immediate and general memory, as evidenced by Wechsler Memory Scale III subtest scores for logical memory I (p = 0.007), verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006), verbal paired associates II (p = 0.031), faces II (p = 0.014), and family pictures II (p = 0.006). The treatment group also demonstrated significantly greater improvement in executive function, sustained attention, and information-processing speed as indicated by scores on the Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009).
Jessica M Gannon 1, Jaspreet Brar, Abhishek Rai, K N Roy Chengappa 2019 May;31(2):123-129
Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial
Results: Medium effect sizes of 0.683 (95% confidence interval [CI], 0.16 to 1.21) and 0.686 (95% CI, 0.16 to 1.21) favoring WSE over placebo were observed for depression single-item and anxiety-depression cluster scores, respectively. Adverse events were mild and transient.
Conclusions: Our findings suggest that WSE may hold promise in the treatment of depression and anxiety symptoms in schizophrenia. While the mechanism of its clinical efficacy requires more exploration, the data suggest.
*These statements have not been evaluated by the federal drug administration. This Product is not intended to diagnose, treat, cure, or prevent any disease.