ABOUT FOCUS WHAT FOCUS DOES HOW FOCUS WORKS Focus + Memory + Mood Support Supplement Gluten-Free Vegan Friendly Non-GMO 3rd Party Tested CGMP Manufcatured Enjoyed by: Creators Entrepreneurs Adventurers Photographers Pod-Casters Streamers Gamers Extreme Sports Athletes WHAT IS CORE CULTURE FOCUS® SUPPLEMENT? Core Culture®...
100% GRASS FED COLLAGEN Skin + Hair + Nails 0g sugar Serving Size: 2 Scoops (20g) 20g Collagen per serving Promotes skin, hair, and nails 100% Grass-Fed Collagen promotes healthy hair, strong nails and supports skin elasticity It also helps to reduce signs of...
CORE CULTURE® MUSHROOM IMMUNITY SUPPLEMENT WHAT IS MUSHROOM IMMUNITY HOW IT WORKS INGREDIENTS Immune Support & Gut Health Supplement Improves Immune response + Physical Endurance + Natural Energy Contains 100% organic mushroom ingredients Boasts a premium formula designed to support natural immune & gut...
Southern & Eastern India, Australia, Europe, Africa, Asia, North & South America
Traditionally, Bacopa was used in ancient practice in various conditions afflicting the mind and nervous system. Studies suggest that Bacopa monnieri decreases the rate of forgetting newly acquired information in healthy adults, and may improve cognitive processes in healthy humans*.
How Bacopa Works
How do phytocemical Bacosides found in Bacopa Work?
Bacosides attribute to the neuroprotective function mainly through modulating antioxidant enzymes, namely, SOD, catalase, etc. Bacosides also regulate the levels of different neurotransmitters in the brain. Interestingly, bacosides do not exert any side effects as proven both in animal models and in human volunteers.
Neuro Protective Support
Emerging research demonstrates several mechanisms of action—acetylcholinesterase inhibition, choline acetyltransferase activation.
Neuropharmacological Review of the Nootropic Herb Bacopa monnieri
Abstract: This review synthesizes behavioral research with neuromolecular mechanisms putatively involved with the low-toxicity cognitive enhancing action of Bacopa monnieri (BM), a medicinal Ayurvedic herb. BM is traditionally used for various ailments, but is best known as a neural tonic and memory enhancer. Numerous animal and in vitro studies have been conducted, with many evidencing potential medicinal properties. Several randomized, double-blind, placebo-controlled trials have substantiated BM's nootropic utility in humans. There is also evidence for potential attenuation of dementia, Parkinson's disease, and epilepsy. Current evidence suggests BM acts via the following mechanisms—antioxidant neuroprotection (via redox and enzyme induction), acetylcholinesterase inhibition and/or choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation (acetylcholine [ACh], 5-hydroxytryptamine [5-HT], dopamine [DA]). BM appears to exhibit low toxicity in model organisms and humans; however, long-term studies of toxicity in humans have yet to be conducted. This review will integrate molecular neuroscience with behavioral research.
About Bacosides: The main nootropic constituents of BM are believed to be dammarane types of triterpenoid saponins known as bacosides, with jujubogenin or pseudo-jujubogenin moieties as aglycone units.38 Bacosides comprise a family of 12 known analogs.39 Novel saponins called bacopasides I–XII have been identified more recently.40–42 The alkaloids brahmine, nicotine, and herpestine have been catalogued, along with d-mannitol, apigenin, hersaponin, monnierasides I–III, cucurbitacins and plantainoside B.43–50 The constituent most studied has been bacoside A, which was found to be a blend of bacoside A3, bacopacide II, bacopasaponin C, and a jujubogenin isomer of bacosaponin C.48 These assays have been conducted using whole plant extract, and bacoside concentrations may vary depending upon the part from which they are extracted.
In one BM sample, Rastogi et al. found this bacoside profile—bacopaside I (5.37%), bacoside A3 (5.59%), bacopaside II (6.9%), bacopasaponin C isomer (7.08%), and bacopasaponin C (4.18%).66 The complete assay of BM is an ongoing effort.