Lower Blood Pressure*
RealMaitake® is a registered trademark of Nammex Organic Mushroom Extracts®
Where MAITAKE is found
History: Maitake is a choice edible that only recently has been utilized for its medicinal properties. Today it is extensively cultivated on sawdust substrates. During the 1990’s Japanese scientists led by Dr. Hiroki Nanba carried out extensive research demonstrating the activity of Maitake beta-glucans as immune system potentiators. Their research identified and commercialized a concentrated beta-glucan called D-fraction or MT-1.
How BETA GLUCANS WORK
Beta Glucans classify as a Dietary Fiber
What does Beta Glucans actually do?
Beta glucan is one form of soluble dietary fiber that's strongly linked to improving cholesterol levels and boosting heart health. Immune Support Beta-glucans might lower blood cholesterol by preventing the absorption of cholesterol from food in the stomach and intestines, when it is taken by mouth.
Gut Health Prebiotic
beta-glucans have been demonstrated to have prebiotic properties owing to their ability to pass undigested through the gastro-intestinal tract (G.I.)
As a soluble fiber, beta-glucan itself is not digested, but it does slow food transit in the intestines. As a result, carbohydrates are absorbed slower, resulting in more steady blood sugar. In addition, it moves slowly through the digestive tract, taking cholesterol with it as it goes.
Studies have shown that they may slightly lower total cholesterol and LDL ("bad") cholesterol. However, they do not seem to affect HDL ("good") cholesterol and triglycerides. Learn more about the benefits of Maitake Mushrooms.
What is Matiake made from ?
Organically grown RealMaitake® from Nammex mushroom is processed by hot water extraction into a fine powder suitable for encapsulation or beverages.
What is the intended use of Maitake?
- Stimulates the immune response
- May improve metabolic health
- May have anti-cancer effects*
- May induce ovulation*
The intended use for Maitake mushroom is to help lower blood pressure in such a way that promotes healthy G.I. gut biom. A healthy biom in turn increases immune system defenses to help fight tumors, stimulate the immune system, and lower blood sugar levels.*
What is the recommended dosage of Maitake?
The clinically substantiated dosing of Maitake mushroom is broad, and often disputed. Based on the results of both first hand independant extrapolation from non-experts and clinical studies, so-called "disease-prevention" doses of commercial preparations of Maitake range from 12 to 25 mg of the extract and 200 to 250 mg or 500 to 2,500 mg of whole powder daily. A trial among HIV-positive patients used doses of 6 g/day whole powder or 20 mg purified extract with 4 g whole maitake powder.
How long does it take for the effects to be felt?
Matiake mushrooms are not commonly "felt" like most supplements. Instead, it's what you don't feel that lets you know it's working. For example, if you don't feel tired and lethargic as often, that is a good sign it is working. Also, if you don't feel sick or weak, this is also a good sign that it is working. Mushrooms also help increase overall endurance, so your exercise endurance should improve in the following weeks from onset of daily dosing.
Matiake mushroom and beta glucans from mushrooms relies on adequate blood-saturation. Meaning that, before effects of Maitake and beta glucans as a whole require daily usage of at least 200mg for no less than 30 days to reach blood saturation. After that period the effects of maitake mushroom will seem more noticeable.
A good way to gauge to test the effects of Maitake mushroom is to monitor your blood pressure. Your blood pressure is an indication of blood saturation. BP levels should lower and level off with regular mushroom maitake consumption use.
What is the mechanism of Maitake Mushroom?
The primary constituent of maitake mushroom is attributed to it's high-yield potency of Beta Glucans, also seen as β-Glucans. β-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well studied, it is still unclear how β-glucans exert their activities. However, recent studies on the β-glucan receptors shed some light on their mechanism of action. Since β-glucans have large molecular weights, they must bind surface receptors to activate immune cells.*
The abstract clinical study on the chemistry of Beta Glucans can be viewed here
Stimulatory Effect of β-glucans on Immune Cells
Published online 2011 Aug 31. doi: 10.4110/in.2011.11.4.191
Read Full Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202617/
β-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well studied, it is still unclear how β-glucans exert their activities. However, recent studies on the β-glucan receptors shed some light on their mechanism of action. Since β-glucans have large molecular weights, they must bind surface receptors to activate immune cells. In this review, we summarize the immunopharmacological activities and the potential receptors of β-glucans in immune cells.
CHEMISTRY OF β-GLUCANS
β-Glucans are heterogeneous polysaccharides of glucose polymer, consisting of a backbone of β-(1-3)-linked β-D-glucopyranosyl units with β-(1-6)-linked side chains of varying distribution and length. The activity of β-glucan depends on the molecular structure, size, branching frequency, structural modification, conformation, and solubility. It appears that the most active forms of β-glucans contain β-(1-3)(1-6) linkages (1). The structure of several biologically active β-glucans has been reported. β-Glucan from many mushrooms has a β-(1-3) backbone with shorter β-(1-6) linked branches, while β-glucan from Alcaligenes faecalis contains only β-(1-3)-glucosidic linkages (2). Schizophyllan from Schizophyllum commune and scleroglucan from Sclerotium glucanicum both have a β-(1→3) linked backbone with one β-(1→6)-glucose substitution every three backbone residues (3). Lentinan from Lentinus edodes has a β-(1→3) linked backbone and two β-(1→6) side chains every five residues (4). β-Glucan from oat and barley are linear with β-(1-4) linkage with shorter stretches of β-(1-3) (3).
Biologically active β-glucans usually have a large molecular weight. However, it is unclear whether β-glucans having intermediate or small molecular weight have biological activities, although some of them are active in vivo. Short β-glucans below 5,000-10,000 Da of molecular weight are generally inactive (5). The optimal branching frequency is suggested as 0.2 (1 in 5 backbone residues) to 0.33. Although unbranched β-glucan curdlan showed proper biological activity, chemical addition of β-(1-6) glucose residues to the curdlan backbone led to an increase in anti-tumor activity (6), as highly branched β-glucan has higher affinity for cognate receptors (7). Furthermore, soluble β-glucans appear to be stronger immunostimulators than insoluble ones. When insoluble scleroglucan is modified by sulfation or carboxymethylation, the anti-tumor activity increases (8).
Further study is still required before we will fully understand the structure-activity relationship in β-glucans. Orally administered β-glucans may be modified to smaller oligosaccharides in vivo (3). Thus, the actual β-glucans binding to the immune cell surface receptors in vivo may in fact be these smaller ones. However, there is no information on this topic to date. If we can use standardize smaller β-glucans, the biological data might be fruitful.
β-Glucans are potent immunomodulators that have multiple activities such as anti-tumor and anti-infective activities. However, how β-glucan exerts these diverse biological activities is still unknown. The first step mediating β-glucan action might be immunostimulation. In particular, binding of β-glucan to specific receptors in macrophages and dendritic cells can induce the production of various cytokines, indirectly activating other immune cells such as T cells and B cells under in vivo conditions. Systemic immunostimulation might be the main route in preventing the growth of cancer cells and infective microorganisms in the host. Several β-glucan receptors in macrophages and dendritic cells, such as dectin-1 and TLRs, might play a key role in the recognition of β-glucans, but the exact signaling pathways downstream from the respective receptors and the cross-talk between them is unclear to date. If we can understand these issues in greater detail, β-glucans might be widely used in the therapy of cancer and infectious diseases.
- Nanba H., Hamaguchi A., Kuroda H. “The Chemical Structure of a Polysaccharide in Fruit Bodies of Grifola frondosa (Maitake)”, Chem. Pharm. Bull. 35 (3) 1987
- Hishida I., Nanba H., Kuroda H., Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake), Chem. Pharm Bull. 36 (5) 1988
- Adachi K., Nanba H., Kuroda H., Potentiation of Host-Mediated Activity in Mice by b-glucan obtained from Grifola frondosa (Maitake), Chem. Pharm Bull. 35 (1) 1987